diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6b1af7997c7adb668c82012dec8cbece7eb37c92..0e53bb972707e1d8dfb53eeef07a3deaff632b63 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,8 @@ Note that since we don't clearly distinguish between a public and private interf
 
 ## [Unreleased]
 
+- Support for ``powerPreference`` webgl attribute. Add ``PluginConfig.General.PowerPreference`` and ``power-preference`` Viewer GET param.
+
 ## [v3.25.1] - 2022-11-20
 
 - Fix edge-case in `Structure.eachUnitPair` with single-element units
diff --git a/src/apps/viewer/app.ts b/src/apps/viewer/app.ts
index 93920c9d94511f926731d070b237c4ca0012c379..3d488ae366147da4cb8ae7c88d1716c322e41da5 100644
--- a/src/apps/viewer/app.ts
+++ b/src/apps/viewer/app.ts
@@ -91,6 +91,7 @@ const DefaultViewerOptions = {
     enableDpoit: PluginConfig.General.EnableDpoit.defaultValue,
     preferWebgl1: PluginConfig.General.PreferWebGl1.defaultValue,
     allowMajorPerformanceCaveat: PluginConfig.General.AllowMajorPerformanceCaveat.defaultValue,
+    powerPreference: PluginConfig.General.PowerPreference.defaultValue,
 
     viewportShowExpand: PluginConfig.Viewport.ShowExpand.defaultValue,
     viewportShowControls: PluginConfig.Viewport.ShowControls.defaultValue,
@@ -163,6 +164,7 @@ export class Viewer {
                 [PluginConfig.General.EnableDpoit, o.enableDpoit],
                 [PluginConfig.General.PreferWebGl1, o.preferWebgl1],
                 [PluginConfig.General.AllowMajorPerformanceCaveat, o.allowMajorPerformanceCaveat],
+                [PluginConfig.General.PowerPreference, o.powerPreference],
                 [PluginConfig.Viewport.ShowExpand, o.viewportShowExpand],
                 [PluginConfig.Viewport.ShowControls, o.viewportShowControls],
                 [PluginConfig.Viewport.ShowSettings, o.viewportShowSettings],
diff --git a/src/apps/viewer/index.html b/src/apps/viewer/index.html
index 71d41ff6787f13b3ac4a0f40a3d57a1a0fd25cad..9918dd47d8ca700c3e4b2c4d2c9f454eb8e5a53a 100644
--- a/src/apps/viewer/index.html
+++ b/src/apps/viewer/index.html
@@ -63,6 +63,7 @@
             var enableDpoit = getParam('enable-dpoit', '[^&]+').trim() === '1';
             var preferWebgl1 = getParam('prefer-webgl1', '[^&]+').trim() === '1' || void 0;
             var allowMajorPerformanceCaveat = getParam('allow-major-performance-caveat', '[^&]+').trim() === '1';
+            var powerPreference = getParam('power-preference', '[^&]+').trim().toLowerCase();
 
             molstar.Viewer.create('app', {
                 layoutShowControls: !hideControls,
@@ -80,6 +81,7 @@
                 enableDpoit: enableDpoit ? true : void 0,
                 preferWebgl1: preferWebgl1,
                 allowMajorPerformanceCaveat: allowMajorPerformanceCaveat,
+                powerPreference: powerPreference || 'high-performance',
             }).then(viewer => {
                 var snapshotId = getParam('snapshot-id', '[^&]+').trim();
                 if (snapshotId) viewer.setRemoteSnapshot(snapshotId);
diff --git a/src/mol-canvas3d/canvas3d.ts b/src/mol-canvas3d/canvas3d.ts
index ed05d3a357ba32df5d8d88e57981a2b654d5c205..b65f42eb74df809aabf86620e4d5cbd07f911673 100644
--- a/src/mol-canvas3d/canvas3d.ts
+++ b/src/mol-canvas3d/canvas3d.ts
@@ -120,6 +120,7 @@ interface Canvas3DContext {
 
 namespace Canvas3DContext {
     export const DefaultAttribs = {
+        powerPreference: 'high-performance' as WebGLContextAttributes['powerPreference'],
         failIfMajorPerformanceCaveat: false,
         /** true by default to avoid issues with Safari (Jan 2021) */
         antialias: true,
@@ -140,8 +141,9 @@ namespace Canvas3DContext {
 
         if (a.enableWboit && a.enableDpoit) throw new Error('Multiple transparency methods not allowed.');
 
-        const { failIfMajorPerformanceCaveat, antialias, preserveDrawingBuffer, pixelScale, preferWebGl1 } = a;
+        const { powerPreference, failIfMajorPerformanceCaveat, antialias, preserveDrawingBuffer, pixelScale, preferWebGl1 } = a;
         const gl = getGLContext(canvas, {
+            powerPreference,
             failIfMajorPerformanceCaveat,
             antialias,
             preserveDrawingBuffer,
diff --git a/src/mol-plugin/config.ts b/src/mol-plugin/config.ts
index 8d097a20047244701bc05f203d6764ecc7ef274c..11ccf25798e2e9c5fe07f8a93a249ae6d530db10 100644
--- a/src/mol-plugin/config.ts
+++ b/src/mol-plugin/config.ts
@@ -37,6 +37,7 @@ export const PluginConfig = {
         // TODO: check back in a few weeks to see if it was fixed
         PreferWebGl1: item('plugin-config.prefer-webgl1', PluginFeatureDetection.preferWebGl1),
         AllowMajorPerformanceCaveat: item('plugin-config.allow-major-performance-caveat', false),
+        PowerPreference: item<WebGLContextAttributes['powerPreference']>('plugin-config.power-preference', 'high-performance'),
     },
     State: {
         DefaultServer: item('plugin-state.server', 'https://webchem.ncbr.muni.cz/molstar-state'),
diff --git a/src/mol-plugin/context.ts b/src/mol-plugin/context.ts
index fd315a57e306cd784e6d3286fafd8fcf2e26a1a6..92fd7bfaa2724b7ecdbeeb0c88274b3d3727e6b9 100644
--- a/src/mol-plugin/context.ts
+++ b/src/mol-plugin/context.ts
@@ -267,7 +267,8 @@ export class PluginContext {
                 const enableDpoit = this.config.get(PluginConfig.General.EnableDpoit) || false;
                 const preferWebGl1 = this.config.get(PluginConfig.General.PreferWebGl1) || false;
                 const failIfMajorPerformanceCaveat = !(this.config.get(PluginConfig.General.AllowMajorPerformanceCaveat) ?? false);
-                (this.canvas3dContext as Canvas3DContext) = Canvas3DContext.fromCanvas(canvas, this.managers.asset, { antialias, preserveDrawingBuffer, pixelScale, pickScale, pickPadding, enableWboit, enableDpoit, preferWebGl1, failIfMajorPerformanceCaveat });
+                const powerPreference = this.config.get(PluginConfig.General.PowerPreference) || 'high-performance';
+                (this.canvas3dContext as Canvas3DContext) = Canvas3DContext.fromCanvas(canvas, this.managers.asset, { antialias, preserveDrawingBuffer, pixelScale, pickScale, pickPadding, enableWboit, enableDpoit, preferWebGl1, failIfMajorPerformanceCaveat, powerPreference });
             }
             (this.canvas3d as Canvas3D) = Canvas3D.create(this.canvas3dContext!);
             this.canvas3dInit.next(true);