diff --git a/src/mol-model-props/pdbe/themes/structure-quality-report.ts b/src/mol-model-props/pdbe/themes/structure-quality-report.ts
index a527e58f7797addf3ad4b2a3de9109c5179f330b..928298bd293b60de2d5673ae174134a9dca1d75a 100644
--- a/src/mol-model-props/pdbe/themes/structure-quality-report.ts
+++ b/src/mol-model-props/pdbe/themes/structure-quality-report.ts
@@ -31,7 +31,7 @@ const ValidationColorTable: [string, Color][] = [
 export function StructureQualityReportColorTheme(ctx: ThemeDataContext, props: {}): ColorTheme<{}> {
     let color: LocationColor
 
-    if (ctx.structure && ctx.structure.models[0].customProperties.has(StructureQualityReport.Descriptor)) {
+    if (ctx.structure && !ctx.structure.isEmpty && ctx.structure.models[0].customProperties.has(StructureQualityReport.Descriptor)) {
         const getIssues = StructureQualityReport.getIssues;
         color = (location: Location) => {
             if (StructureElement.isLocation(location)) {
diff --git a/src/mol-model-props/rcsb/themes/assembly-symmetry-cluster.ts b/src/mol-model-props/rcsb/themes/assembly-symmetry-cluster.ts
index efe1bb6fba7c3b5ab1453c7080ec3cb4c2f036b7..434187445d789c4f3419c363e4e936b849a2b2b1 100644
--- a/src/mol-model-props/rcsb/themes/assembly-symmetry-cluster.ts
+++ b/src/mol-model-props/rcsb/themes/assembly-symmetry-cluster.ts
@@ -47,7 +47,7 @@ export function AssemblySymmetryClusterColorTheme(ctx: ThemeDataContext, props:
 
     const { symmetryId } = props
 
-    if (ctx.structure && ctx.structure.models[0].customProperties.has(AssemblySymmetry.Descriptor)) {
+    if (ctx.structure && !ctx.structure.isEmpty && ctx.structure.models[0].customProperties.has(AssemblySymmetry.Descriptor)) {
         const assemblySymmetry = AssemblySymmetry.get(ctx.structure.models[0])!
 
         const s = assemblySymmetry.db.rcsb_assembly_symmetry
@@ -99,5 +99,5 @@ export const AssemblySymmetryClusterColorThemeProvider: ColorTheme.Provider<Asse
     factory: AssemblySymmetryClusterColorTheme,
     getParams: getAssemblySymmetryClusterColorThemeParams,
     defaultValues: PD.getDefaultValues(AssemblySymmetryClusterColorThemeParams),
-    isApplicable: (ctx: ThemeDataContext) => !!ctx.structure && ctx.structure.models[0].customProperties.has(AssemblySymmetry.Descriptor)
+    isApplicable: (ctx: ThemeDataContext) => !!ctx.structure && !ctx.structure.isEmpty && ctx.structure.models[0].customProperties.has(AssemblySymmetry.Descriptor)
 }
\ No newline at end of file
diff --git a/src/mol-model/structure/structure/structure.ts b/src/mol-model/structure/structure/structure.ts
index d7b99e9ff018db30162d37aae9a615c2892c2e20..b1c520601104772ffeba27c674deae65e2325d88 100644
--- a/src/mol-model/structure/structure/structure.ts
+++ b/src/mol-model/structure/structure/structure.ts
@@ -72,6 +72,10 @@ class Structure {
         return prc && ec ? ec / prc < 2 : false
     }
 
+    get isEmpty() {
+        return this.units.length === 0;
+    }
+
     get hashCode() {
         if (this._props.hashCode !== -1) return this._props.hashCode;
         return this.computeHash();
diff --git a/src/mol-plugin/behavior/dynamic/custom-props/pdbe/structure-quality-report.ts b/src/mol-plugin/behavior/dynamic/custom-props/pdbe/structure-quality-report.ts
index 61a09e969723d1c0d28ece8064cee69b88f11b95..6c09982015da5a9d71bba13f2351d6dd8d40df83 100644
--- a/src/mol-plugin/behavior/dynamic/custom-props/pdbe/structure-quality-report.ts
+++ b/src/mol-plugin/behavior/dynamic/custom-props/pdbe/structure-quality-report.ts
@@ -40,7 +40,7 @@ export const PDBeStructureQualityReport = PluginBehavior.create<{ autoAttach: bo
                 factory: StructureQualityReportColorTheme,
                 getParams: () => ({}),
                 defaultValues: {},
-                isApplicable: (ctx: ThemeDataContext) => !!ctx.structure && ctx.structure.models[0].customProperties.has(StructureQualityReport.Descriptor)
+                isApplicable: (ctx: ThemeDataContext) => !!ctx.structure && !ctx.structure.isEmpty && ctx.structure.models[0].customProperties.has(StructureQualityReport.Descriptor)
             })
         }